In search of the grail: the never-ending story of biomarkers for coronary risk prediction.

“I was brought up in an older tradition. I was told: “before ordering a test decide what you will do if it is (a) positive, or (b) negative, and if both answers are the same don’t do the test. At the other end of the scale is the most recent innovation whereby a package of results of a dozen tests arrive at the bedside almost before the signs and symptoms have been elicited” A. Cochrane. Effectiveness and efficiency, p. 43.